Guanethidine-Resistant Hypertension

Guanethidine-resistant hypertension.

Resistance of hypertensive patients to large doses of guanethidine is seldom due to defective absorption of the drug, since the existence of adrenergic blockade can be demonstrated in these cases. The effect on the blood pressure of intravenous phenoxybenzamine and norepinephrine, respectively, has been compared in groups of hypertensive patients resistant and responsive to guanethidine. As bot...

Guanethidine in the Treatment of Hypertension.

Guanethidine in the treatment of severe hypertension.

Obstetrics in General Practice-A Five-year Survey. H. I. HOWARD. The Practitioner(Feburary 1962) 188, 239 and 383. Dr Howard reports on 419obstetric patients under his carebetween 1952 and 1957. He describes the arrangements for ante-natal care and the method for liaison with the consultant and hospital service. Part II of his paper is a detailed analysis of hisresults, and ...

Comparison of debrisoquine and guanethidine in treatment of hypertension.

A cross-over trail of debrisoquine and guanethidine in 32 patients showed that both drugs were equally effective in lowering both systolic and diastolic blood pressure. The degree to which they were tolerated by the patients, however, differed greatly. After three months on each drug 18 patients preferred debrisoquine, nine preferred guanethidine, and five showed no particular preference. At cu...

Resistant Hypertension

High blood pressure (BP) is the leading risk factor for premature death and disability-adjusted life years in the world. The development of a large pharmaceutical base from which to manage patients with hypertension in addition to many patient years of clinical trial experience have made it possible to successfully manage many of these patients. Nonetheless, many questions remain, particularly ...